Immunology and Immunotherapy

Immune Tolerance

Immune tolerances are often defined as a state during which a T -cell cannot answer antigen. The T cell "tolerates" the antigen. A state of unresponsiveness to a specific antigen or group of antigens to which a private is usually responsive. Immune tolerance is achieved under conditions that suppress the immune response and is not just the absence of an immune reaction. it's the prevention of an immune reaction against a specific antigen. as an example, the system is usually tolerant of self-antigens, so it doesn't usually attack the body's own cells, tissues, and organs. However, when tolerance is lost, disorders like autoimmune disease or allergy may occur. Encompasses the range of physiological mechanisms by which the body reduces or eliminates an immune response to particular agents. Typically, a change within the host, not the antigen, is implied. Though some pathogens can evolve to subside virulent in host-pathogen coevolution, tolerance doesn't ask the change within the pathogen, but are often wont to describe the changes in host physiology. Nor does it ask other kinds of non-reactivity like immunological paralysis.

• Central tolerance
• Peripheral tolerance
• Allograft tolerance
• Foetal development
• Fetomaternal tolerance